![]() ![]() Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of serious adverse cardiovascular (CV) events, including acute myocardial infarction (MI), cerebrovascular accident, and CV death. PIRRT (eg, sustained, low-efficiency diafiltration): Avoid use ( Ref). Peritoneal dialysis: Avoid use, as patients with end-stage kidney disease may be at increased risk for bleeding (eg, GI), cardiovascular adverse effects, and loss of residual kidney function ( Ref). Hemodialysis, intermittent (thrice weekly): Not significantly dialyzable ( Ref): Avoid use, as patients with end-stage kidney disease may be at increased risk for bleeding (eg, GI), cardiovascular adverse effects, and loss of residual kidney function ( Ref). ![]() If necessary, use the lowest effective dose for the shortest duration possible avoid in patients at high risk for acute kidney injury (ie, volume depleted, hypotensive, elderly, or taking concurrent nephrotoxic medications) ( Ref).ĬrCl ≤30 mL/minute: Avoid use due to increased risk of acute kidney injury ( Ref). Use of analgesics other than nonsteroidal anti-inflammatory drugs may be preferred. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC Michael Heung, MD, MS.ĮGFR ≥60 mL/minute/1.73 m 2: No dosage adjustment necessary.ĮGFR 30 to <60 mL/minute: No dosage adjustment necessary ( Ref). Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF Jason A. The renal dosing recommendations are based upon the best available evidence and clinical expertise.
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